Dimethyl malonate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

丙二酸二甲酯是一种琥珀酸脱氢酶抑制剂。

Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.

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Animal Model:Sprague-Dawley male rats, cardiac arrest modelDosage:6 mg/kg/minAdministration:Intravenous infusion, 51 minResult:Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.

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Others

Other Targets

Succinate Dehydrogenase

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108-59-8

132.11

C5H8O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (756.94 mM)

COC(=O)CC(=O)OC

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(-20℃)

With Ice Pack

≥ 2 years