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Dimethyl malonate
CAS No. 108-59-8
Dimethyl malonate ( —— )
产品货号. M20375 CAS No. 108-59-8
丙二酸二甲酯是一种琥珀酸脱氢酶抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | ￥340 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Dimethyl malonate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述丙二酸二甲酯是一种琥珀酸脱氢酶抑制剂。
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产品描述Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.
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体外实验——
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体内实验Animal Model:Sprague-Dawley male rats, cardiac arrest modelDosage:6 mg/kg/minAdministration:Intravenous infusion, 51 minResult:Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.
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同义词——
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通路Others
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靶点Other Targets
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受体Succinate Dehydrogenase
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研究领域——
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适应症——
化学信息
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CAS Number108-59-8
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分子量132.11
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分子式C5H8O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (756.94 mM)
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SMILESCOC(=O)CC(=O)OC
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Xu J Pan H Xie X et .al.Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest[J].Neuroscience. 2018 Nov 21;393:24-32
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